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The effects of aerobic exercise on plasma catecholamines and blood pressure in patients with mild essential hypertension
Duncan JJ, Farr JE, Upton SJ, Hagan RD, Oglesby ME, Blair SN
JAMA 1985 Nov 8;254(18):2609-2613
clinical trial
5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

The effects of a 16-week aerobic exercise program on blood pressure and plasma catecholamine levels were evaluated in 56 patients with baseline diastolic blood pressure of 90 to 140 mmHg. The exercise group significantly improved their physical fitness, and reduced systolic and diastolic blood pressures, compared with controls. To evaluate the relationship between exercise, blood pressure, and plasma catecholamine values, the exercise group was further divided into hyperadrenergic and normoadrenergic subgroups. Reductions in systolic pressures were 6.3 mmHg, 10.3 mmHg, and 15.5 mmHg for control, normoadrenergic, and hyperadrenergic groups, respectively. Diastolic changes were similar and also significant. Within the hyperadrenergic group, changes in blood pressures were associated with changes in values for plasma catecholamines following training. We conclude that an aerobic exercise program reduces blood pressure, which is at least partially mediated by changes in plasma catecholamine levels.

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