BACKGROUND AND PURPOSE: Fatigue is one of the most common disabling complaints in patients with multiple sclerosis (MS). According to recently studies, between 60 to 90% of MS suffer of excessive fatigue. The nature of MS related fatigue is clearly distinct from normal fatigue. Complementary therapies probably effect on reduction of fatigue such as physiotherapy, yoga and exercise therapy. The purpose of this research was to evaluate the effect of aquatic exercise program on fatigue in women with Multiple sclerosis. MATERIALS AND METHODS: Subjects of the research were 26 females with MS, who have age between 25 to 45 years and EDSS 1 to 4. And they were divided into two groups, experimental (12) and control (14). Aquatic Exercise program was 8 weeks (3 x weeks). Fatigue Severity Scale (FSS) used for measure fatigue in patients MS. Software SPSS (16) and T-student method used for statically analysis. RESULTS: Results showed that there were a statically difference between pre and post test FSS scores in experimental group (p < 0.05). Also, there were a statically difference between post-test FSS scores in experimental and control groups (p < 0.05). And was observed that fatigue was significantly decrease after investigation CONCLUSION: Finally, we can state that aquatic exercise program decrease fatigue in people with MS.

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