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Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth |
Shaw M, Savoye M, Cali A, Dziura J, Tamborlane WV, Caprio S |
Diabetes Care 2009 Jan;32(1):45-47 |
clinical trial |
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
OBJECTIVE: To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children. RESEARCH DESIGN AND METHODS: Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study. RESULTS: Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (p = 0.009) and glucose tolerance (p = 0.04). CONCLUSIONS: An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.
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