Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth
Shaw M, Savoye M, Cali A, Dziura J, Tamborlane WV, Caprio S
Diabetes Care 2009 Jan;32(1):45-47
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children. RESEARCH DESIGN AND METHODS: Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study. RESULTS: Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (p = 0.009) and glucose tolerance (p = 0.04). CONCLUSIONS: An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.
Copyright American Diabetes Association. Reprinted with permission from The American Diabetes Association.

Full text (sometimes free) may be available at these link(s):      help