OBJECTIVE: To systematically review the evidence on the effects of an ankle-foot orthosis on gait biomechanics after stroke. DATA SOURCES: The following databases were searched; AMED, CINAHL, Cochrane Library (Stroke section), Medline, PubMed, ScienceDirect and Scopus. Previous reviews, reference lists and citation tracking of the selected articles were screened and the authors of selected trials contacted for any further unpublished data. REVIEW METHODS: Controlled trials of an ankle-foot orthosis on gait biomechanics in stroke survivors were identified. A modified PEDro score evaluated trial quality; those scoring 4/8 or more were selected. Information on the trial design, population, intervention, outcomes, and mean and standard deviation values for the treatment and control groups were extracted. Continuous outcomes were pooled according to their mean difference and 95% confidence intervals in a fixed-effect model. RESULTS: Twenty trials involving 314 participants were selected. An ankle-foot orthosis had a positive effect on ankle kinematics (p < 0.00001 to 0.0002); knee kinematics in stance phase (p < 0.0001 to 0.01); kinetics (p = 0.0001) and energy cost (p = 0.004), but not on knee kinematics in swing phase (p = 0.84), hip kinematics (p < 0.18 to 0.89) or energy expenditure (p = 0.43). There were insufficient data for pooled analysis of individual joint moments, muscle activity or spasticity. All trials, except one, evaluated immediate effects only. CONCLUSIONS: An ankle-foot orthosis can improve the ankle and knee kinematics, kinetics and energy cost of walking in stroke survivors.

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