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Racial differences in the response of cardiorespiratory fitness to aerobic exercise training in caucasian and African American postmenopausal women |
Swift DL, Johannsen NM, Lavie CJ, Earnest CP, Johnson WD, Blair SN, Church TS, Newton RL Jr |
Journal of Applied Physiology 2013 May;114(10):1375-1382 |
clinical trial |
5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
African American (AA) women have an elevated risk of cardiovascular disease and have been reported to have lower cardiorespiratory fitness (CRF) compared with caucasian American (CA) women. However, little data exist that evaluate racial differences in the change in CRF following aerobic exercise training. CA (n = 264) and AA (n = 122) postmenopausal women from the Dose-Response to Exercise in Women study were randomized to 4, 8, and 12 kcal/kg body wt/wk (KKW) of aerobic training or the control group for 6 mo. CRF was evaluated using a cycle ergometer. A greater increase in relative CRF was observed in CA compared with AA women in the 4 (CA 1.00 versus AA 0.35 mlO2/kg/min, p = 0.034), 8 (CA 1.59 versus AA 0.82 mlO2/kg/min, p = 0.041), and 12 (CA 1.98 versus AA 0.50 mlO2/kg/min, p = 0.001) KKW groups. Similar effects were found in absolute CRF, with the exception of the 4-KKW (CA 0.04 versus AA 0.02 lO2/min, p = 0.147) group. However, in categorical analyses, the percentages of women who improved in both relative (> 0 mlO2/kg/min) and absolute (> 0 lO2/min) CRF were not significantly different for CA and AA women in all exercise groups (all p > 0.05). AA postmenopausal women, in general, had an attenuated increase in CRF (both relative and absolute) following exercise training, but had similar response rates compared with CA women. Future studies should investigate the physiologic mechanisms responsible for this attenuated response.
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