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Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial
Peddie MC, Bone JL, Rehrer NJ, Skeaff CM, Gray AR, Perry TL
The American Journal of Clinical Nutrition 2013 Aug;98(2):358-366
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Sedentary behavior is a risk factor for cardiometabolic disease. Regularly interrupting sedentary behavior with activity breaks may lower this risk. OBJECTIVE: We compared the effects of prolonged sitting, continuous physical activity combined with prolonged sitting, and regular activity breaks on postprandial metabolism. DESIGN: Seventy adults participated in a randomized crossover study. The prolonged sitting intervention involved sitting for 9 h, the physical activity intervention involved walking for 30 min and then sitting, and the regular-activity-break intervention involved walking for 1 min 40 s every 30 min. Participants consumed a meal-replacement beverage at 60, 240, and 420 min. RESULTS: The plasma incremental area under the curve (iAUC) for insulin differed between interventions (overall p < 0.001). Regular activity breaks lowered values by 866.7 IU/L/9-h (95% CI 506.0 to 1,227.5 IU/L/9-h; p < 0.001) when compared with prolonged sitting and by 542.0 IU/L/9-h (95% CI 179.9 to 904.2 IU/L/9-h; p = 0.003) when compared with physical activity. Plasma glucose iAUC also differed between interventions (overall p < 0.001). Regular activity breaks lowered values by 18.9 mmol/L/9-h (95% CI 10.0 to 28.0 mmol/L/9-h; p < 0.001) when compared with prolonged sitting and by 17.4 mmol/L/9-h (95% CI 8.4 to 26.3 mmol/L/9-h; p < 0.001) when compared with physical activity. Plasma triglyceride iAUC differed between interventions (overall p = 0.023). Physical activity lowered values by 6.3 mmol/L/9-h (95% CI 1.8 to 10.7 mmol/L/9-h; p = 0.006) when compared with regular activity breaks. CONCLUSION: Regular activity breaks were more effective than continuous physical activity at decreasing postprandial glycemia and insulinemia in healthy, normal-weight adults. This trial was registered with the Australian New Zealand Clinical Trials registry as ACTRN12610000953033.
Copyright by the American Society for Clinical Nutrition.

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