BACKGROUND: The data on cost savings with disease management (DM) in chronic obstructive pulmonary disease (COPD) is limited. A multicomponent DM program in COPD has recently shown in a large randomized controlled trial to reduce hospitalizations and emergency department visits compared to usual care (UC). The objectives of this study were to determine the cost of implementing the DM program and its impact on healthcare resource utilization costs compared to UC in high-risk COPD patients. MATERIALS AND METHODS: This study was a post-hoc economic analysis of a multicenter randomized, adjudicator-blinded, controlled, 1-year trial comparing DM and UC at 5 Midwest region Department of Veterans Affairs (VA) medical centers. Health-care costs (hospitalizations, ED visits, respiratory medications, and the cost of the DM intervention) were compared in the COPD DM intervention and UC groups. RESULTS: The composite outcome for all hospitalizations or ED visits were 27% lower in the DM group (123.8 mean events per 100 patient-years) compared to the UC group (170.5 mean events per 100 patient-years) (rate ratio 0.73; 0.56 to 0.90; p < 0.003). The cost of the DM intervention was $241,620 or $650 per patient. The total mean +/- SD per patient cost that included the cost of DM in the DM group was $4,491 +/- 4,678 compared to $5,084 +/- 5,060 representing a $593 per patient cost savings for the DM program. CONCLUSIONS: The DM intervention program in this study was unique for producing an average cost savings of $593 per patient after paying for the cost of DM intervention.

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