OBJECTIVE: Antidepressants may attenuate the effects of diet and exercise programs. We compared adherence and changes in body measures and biomarkers of glucose metabolism and inflammation between antidepressant users and non-users in a 12-month randomized controlled trial. METHODS: Overweight or obese, postmenopausal women were assigned to: diet (10% weight loss goal, n = 118); moderate-to-vigorous aerobic exercise (225min/week, n = 117); diet+exercise (n = 117); and control (n = 87) in Seattle, WA 2005 to 2009. Women using antidepressants at baseline were classified as users (n = 109). ANCOVA and generalized estimating equation approaches, respectively, were used to compare adherence (exercise amount, diet session attendance, and changes in percent calorie intake from fat, cardiopulmonary fitness, and pedometer steps) and changes in body measures (weight, waist and percent body fat) and serum biomarkers (glucose, insulin, homeostasis assessment-insulin resistance, and high-sensitivity c-reactive protein) between users and non-users. An interaction term (interventionxantidepressant use) tested effect modification. RESULTS: There were no differences in adherence except that diet session attendance was lower among users in the diet+exercise group (p < 0.05 versus non-users). Changes in body measures and serum biomarkers did not differ by antidepressant use (p-interaction > 0.05). CONCLUSION: Dietary weight loss and exercise improved body measures and biomarkers of glucose metabolism and inflammation independent of antidepressant use.
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