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Effect of a home-based exercise program on functional recovery following rehabilitation after hip fracture: a randomized clinical trial
Latham NK, Harris BA, Bean JF, Heeren T, Goodyear C, Zawacki S, Heislein DM, Mustafa J, Pardasaney P, Giorgetti M, Holt N, Goehring L, Jette AM
JAMA 2014 Feb 19;311(7):700-708
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

IMPORTANCE: For many older people, long-term functional limitations persist after a hip fracture. The efficacy of a home exercise program with minimal supervision after formal hip fracture rehabilitation ends has not been established. OBJECTIVE: To determine whether a home exercise program with minimal contact with a physical therapist improved function after formal hip fracture rehabilitation ended. DESIGN, SETTING, AND PARTICIPANTS: Randomized clinical trial conducted from September 2008 to October 2012 in the homes of 232 functionally limited older adults who had completed traditional rehabilitation after a hip fracture. INTERVENTIONS: The intervention group (n = 120) received functionally oriented exercises (such as standing from a chair, climbing a step) taught by a physical therapist and performed independently by the participants in their homes for 6 months. The attention control group (n = 112) received in-home and telephone-based cardiovascular nutrition education. MAIN OUTCOMES AND MEASURES: Physical function assessed at baseline, 6 months (ie, at completion of the intervention), and 9 months by blinded assessors. The primary outcome was change in function at 6 months measured by the Short Physical Performance Battery (SPPB; range 0 to 12, higher score indicates better function) and the Activity Measure for Post-Acute Care (AM-PAC) mobility and daily activity (range 23 to 85 and 9 to 101, higher score indicates better function). RESULTS: Among the 232 randomized patients, 195 were followed up at 6 months and included in the primary analysis. The intervention group (n = 100) showed significant improvement relative to the control group (n = 95) in functional mobility (mean SPPB scores for intervention group: 6.2 (SD 2.7) at baseline, 7.2 (SD 3) at 6 months; control group: 6.0 (SD 2.8) at baseline, 6.2 (SD 3) at 6 months; and between-group differences 0.8 (95% CI 0.4 to 1.2), p < 0.001; mean AM-PAC mobility scores for intervention group: 56.2 (SD 7.3) at baseline, 58.1 (SD 7.9) at 6 months; control group: 56 (SD 7.1) at baseline, 56.6 (SD 8.1) at 6 months; and between-group difference 1.3 (95% CI 0.2 to 2.4), p = 0.03; and mean AM-PAC daily activity scores for intervention group: 57.4 (SD 13.7) at baseline, 61.3 (SD 15.7) at 6 months; control group: 58.2 (SD 15.2) at baseline, 58.6 (SD 15.3) at 6 months; and between-group difference 3.5 (95% CI 0.9 to 6.0), p = 0.03). In multiple imputation analyses, between-group differences remained significant for SPPB and AM-PAC daily activity, but not for mobility. Significant between-group differences persisted at 9 months for all functional measures with and without imputation. CONCLUSIONS AND RELEVANCE: Among patients who had completed standard rehabilitation after hip fracture, the use of a home-based functionally oriented exercise program resulted in modest improvement in physical function at 6 months after randomization. The clinical importance of these findings remains to be determined. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT00592813.

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