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| Quadriceps strengthening exercises are effective in improving pain, function and quality of life in patients with osteoarthritis of the knee | 
| Imoto AM, Peccin MS, Trevisani VFM | 
| Acta Ortopedica Brasileira 2012 May;20(3):174-179 | 
| clinical trial | 
| 7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* | 
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                     OBJECTIVE: The purpose of this research was to verify the effectiveness of an eight-week quadriceps strengthening program on pain, function and quality of life of patients with knee osteoarthritis. METHODS: A hundred patients were randomized into two groups: (1) exercise group (ExG) and (2) orientation group. The Timed Up and Go (TUG) test, the numerical rating scale (NRS) and the Short Form-36 were used for the assessment. RESULTS: Eighty-one patients completed the survey. According to the intention to treat (ITT) analysis, there was statistically significant difference in ExG compared to OG in all the variables assessed. CONCLUSION: The program quadriceps strengthening exercises applied in this randomized clinical trial was effective in improving pain, function and quality of life of patients with knee osteoarthritis. LEVEL OF EVIDENCE: I, randomized clinical trial.  
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