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Efeitos do exercicio fisico sobre os niveis sericos de serotonina e seu metabolito na fibromialgia: um estudo piloto randomizado (Effects of physical exercise on serum levels of serotonin and its metabolite in fibromyalgia: a randomized pilot study) [Portuguese]
Valim V, Natour J, Xiao Y, Pereira AFA, Lopes BBC, Pollak DF, Zandonade E, Russell IJ
Revista Brasileira de Reumatologia [Brazilian Journal of Rheumatology] 2013 Nov-Dec;53(6):538-541
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

To evaluate the effects of aerobic training and stretching on serum levels of serotonin (5HT) and its main metabolite 5-hydroxindolacetic acid (5HIAA). Twenty-two women with FM were randomized into one of two exercise modalities (aerobic walking exercise or stretching exercise) to be accomplished three times a week for 20 weeks. The serum levels of 5HT and 5HIAA were evaluated before and after the exercise program by high performance liquid chromatography (HPLC) with colorimetric detection. Within group analysis (pre-post) showed that serum levels of both 5HT and 5HIAA changed significantly in the aerobic group during the 20-week course of therapy (5HT: p = 0,03; 5HIAA: p = 0,003). In the stretching group, however, no statistically significant change was observed (5HT: p = 0,491; 5HIAA: p = 0,549). Between group statistical comparisons of laboratory measures disclosed that aerobic training was superior to stretching in that it significantly increased the levels of 5HIAA (F test = 6.61; p = 0.01), but the average difference between groups on the levels of 5HT did not meet significance criteria (F test = 3.42; p = 0.08). Aerobic training increases the 5HIAA and 5HT levels and it could explain why aerobic exercise can improve symptoms in fibromyalgia syndrome patient more than stretching exercise.

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