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(Effects of cocktail treatment on motor function of patients with ischemic stroke) [Chinese - simplified characters]
Pang A-L, Ren H, Chang L-H, Gong S-X, Ma S-P
Zhongguo Linchuang Kangfu [Chinese Journal of Clinical Rehabilitation] 2006 Aug;10(32):6-8
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: No; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

AIM: To study the effects of cocktail treatment on motor function of patients with ischemic stroke. METHODS: Eighty inpatients with acute ischemic stroke of internal carotid system (ICS) were selected from the Department of Neurology, First Affiliated Hospital of Kunming Medical College between January 2004 to March 2005. (1) Subjects were randomly divided into control group (n = 39) and treatment group (n = 41) according to the enrolled sequence with 3 cases in one group. Patients in the control group were given of conventional therapy (expectant treatment, anti-platelet aggregation, decompression by dehydration, neurotrophy, prevention and cure of complications, etc). Based on conventional therapy, patients in treatment group received cocktail treatment (notoginseng saponin, rehabilitation training, electroacupuncture and hyperbaric oxygen treatment). (2) Functional assessment was conducted respectively at enrollment and 3 weeks after treatment. Active ability in daily life was assessed by using revised Barthel Index (BI). The higher the score was, the less the dependence was. Loss of function in limbs were scored by European Stroke Scale (ESS) with the total score of 100 points. The higher the score was, the less the neurofunctional damage was. RESULTS: Two patients in the control group withdrew from the therapy, and a total of 78 cases were involved in the analysis of results. (1) Scores of ESS: those in both groups after treatment were obviously higher than those before treatment (control group 56.58 +/- 16.13, 42.53 +/- 12.02, p = 0.000; treatment group 70.72 +/- 18.07, 44.17 +/- 14.63, p = 0.000). While score of treatment group after treatment was significantly higher than that in the control group (p = 0.000). (2) Scores of BI: those in both groups were remarkably higher than those before treatment (control group 58.37 +/- 14.66, 48.37 +/- 13.37, p = 0.000; treatment group 75.34 +/- 15.36, 51.66 +/- 11.56, p = 0.000). Score in the treatment group after treatment was markedly higher than that in the control group (p = 0.000). CONCLUSION: Cocktail treatment can promote the amelioration of motor function in patients with ischemic stroke.

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