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| The effects of diet- and diet plus exercise-induced weight loss on basal metabolic rate and acylated ghrelin in grade 1 obese subjects |
| Lopes AL, Fayh APT, de Souza Campos LG, Teixeira BC, Carteri RBK, Ribeiro JL, Friedman R, Reischak-Oliveira A |
| Diabetes, Metabolic Syndrome and Obesity 2013 Nov 29;6:469-475 |
| clinical trial |
| 4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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BACKGROUND: Diet and exercise are often prescribed as primary intervention regarding obesity-related disorders. Additionally, recent studies have shown beneficial effects of weight loss through diet and exercise in ghrelin concentrations in obese subjects. The aim of this study was to evaluate the effects of a 5% weight loss on lipid profile, resting metabolic rate (RMR), and acylated ghrelin (AG) using two different methods of intervention (diet or diet plus exercise). MATERIALS AND METHODS: Eighteen subjects (twelve women and six men) aged 20 to 40 years with a body mass index of 30 to 34.9 kg/m2 (grade 1 obesity) were randomized into two intervention groups: diet (n = 9) or diet plus exercise (n = 9). Both groups underwent treatment until 5% of the initial body weight was lost. At baseline and upon completion, RMR and AG were analyzed. RESULTS: Both groups showed a significant decrease in body fat percentage and fat mass. The diet-plus-exercise group showed a decrease in AG (pre 54.4 +/- 25.3 pg/mL and post 33.2 +/- 19.1 pg/mL) and an increase in RMR (pre 1,363 +/- 379 kcal/day, post 1,633 +/- 223 kcal/day). CONCLUSION: These data suggest that diet plus exercise induced weight loss and had beneficial effects on AG concentration and RMR, essential factors to ensure the benefits of a weight-loss program.
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