Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Endurance training is feasible in severely disabled patients with progressive multiple sclerosis
Skjerbaek AG, Naesby M, Lutzen K, Moller AB, Jensen E, Lamers I, Stenager E, Dalgas U
Multiple Sclerosis Journal 2014 Apr;20(5):627-630
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

This study tested whether upper-body endurance training (ET) is feasible and can be performed at sufficient intensity to induce cardiovascular adaptations in severely disabled patients with progressive multiple sclerosis (MS). Eleven progressive MS patients (6.5 <= EDSS <= 8.0) scheduled for a four-week inpatient rehabilitation program were randomized to a control group (CON, n = 5) that received standard individualized MS rehabilitation or an intervention group (EXE, n = 6) that in addition received 10 sessions of predominantly upper-body ET. One patient dropped out of the EXE group (drop-out rate 1/6 about 17%) and no adverse events were recorded. The EXE group completed on average 9.3 +/- 0.8 sessions (about 96.0 +/- 5%). During the ET sessions an average heart rate of 93.9 +/- 9.3 beats/min were sustained corresponding to 91.6 +/- 6.8% of the maximal pre-intervention heart rate. In the EXE group a trend toward a time x group interaction was seen for VO2peak (p = 0.06). ET is feasible in severely disabled patients with progressive MS and it can probably be performed at sufficient intensity to induce cardiovascular adaptations.

Full text (sometimes free) may be available at these link(s):      help