OBJECTIVE: Systematically review frequency and quality of adverse event (AE) reports in randomized clinical trials (RCTs) of Tai Chi (TC). DATA SOURCES: Electronic searches of PubMed/Medline and additional databases from inception through March 2013 of English-language RCTs. Search terms were Tai Chi, Taiji, Tai Chi Chuan. Data were independently extracted by two investigators. STUDY SELECTION: We included all available randomized controlled trials (RCTs) that were published in English and used Tai Chi as an intervention. Inclusion and exclusion of studies were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. DATA EXTRACTION: Eligible RCTs were categorized with respect to AE reporting: (1) no mention of protocols for monitoring AEs or reports of AEs; (2) reports of AEs either with or without explicit protocols for monitoring AEs. DATA SYNTHESIS: 153 eligible RCTs were identified, most targeting older adults. Only 50 eligible trials (33%) included reporting of AEs, and of these, only 18 trials (12% overall) also reported an explicit AE monitoring protocol. Protocols varied with respect to rigor of systematic monitoring in both Tai Chi and comparison groups. Reported AEs were typically minor and expected, and primarily musculoskeletal related (eg, knee and back pain); no intervention-related serious AEs were reported. CONCLUSIONS: Tai Chi is unlikely to result in serious adverse events, but may be associated with minor musculoskeletal aches and pains. However, poor and inconsistent reporting of AEs greatly limits the conclusions that can be drawn regarding the safety of Tai Chi.

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