BACKGROUND AND PURPOSE: Resistin, an adipocyte-derived hormone, plays a key role in regulating energy homeostasis and metabolism. This study aimed at evaluating the role of long-term physical exercise without diet on serum resistin and insulin resistance in middle-aged obese men. MATERIALS AND METHODS: Thirty two middle-aged obese men were randomly divided to experimental and control groups. Fasting insulin, serum resistin and glucose levels were measured before and after three months of physical exercise or detraining in the two groups. Insulin resistance was calculated using fasting glucose and insulin. Data analysis was performed by independent and paired t-tests. RESULTS: There were no significant differences in basal biochemical and anthropometrical variables between the two groups (p > 0.05). In the experimental group, all anthropometrical variables decreased after exercise intervention (p < 0.05), but serum resistin and insulin resistance remained unchanged (p > 0.05). CONCLUSION: Based on the results, it can be concluded that physical exercise in the absence of diet does not affect serum resistin and insulin resistance in obese males.

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