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A pilot randomized trial of progressive resistance exercise augmented by neuromuscular electrical stimulation for people with multiple sclerosis who use walking aids
Coote S, Hughes L, Rainsford G, Minogue C, Donnelly A
Archives of Physical Medicine and Rehabilitation 2015 Feb;96(2):197-204
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To investigate the feasibility and preliminary outcomes of a home progressive resistance training program augmented by neuromuscular electrical stimulation. DESIGN: Randomized, controlled, pilot trial. SETTING: Participants home. PARTICIPANTS: People with multiple sclerosis (n = 37) who use a walking aid. INTERVENTIONS: Twelve week home PRT program or the same augmented by NMES. MAIN OUTCOME MEASURES: Strength using hand held dynamometry, repeated sit to stand test, Berg Balance Scale, Timed Up and Go test (TUG), MS walking scale 12, MS Impact Scale 29v2, modified Fatigue Impact Scale and the NMES group completed a device usability questionnaire. RESULTS: Only change in MFIS score was significantly greater in the NMES than the PRT group (p = 0.012). The NMES group improved significantly in quadriceps endurance (median of change 8.5, p = 0.043), balance (3.5, p = 0.001), physical impact of MS (-8.3, p = 0.001) and impact of fatigue (-17, p = 0.001). Participants rated the device as highly usable. CONCLUSION: This pilot study suggests that a home PRT program with NMES is feasible and the Kneehab device is usable by this population. Only the reduction in impact of fatigue was greater in the NMES than the PRT group.

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