Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Osteogenic effects of a physical activity intervention in South African black children
Meiring RM, Micklesfield LK, Avidon I, McVeigh JA
Journal of Musculoskeletal & Neuronal Interactions 2014 Sep;14(3):276-285
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVES: To determine whether a weight-bearing physical activity intervention improves measures of bone density, size and strength in a pre- and early pubertal cohort of black South African children. METHODS: Twenty two school children (9.7 +/- 1.1 years) were cluster randomised into an exercise (EX; n = 12) and control (CON; n = 10) group. EX children performed a weight-bearing exercise program for 20 weeks. CON children continued their regular activities. Whole body DXA and tibial peripheral QCT scans were obtained. Urine was analysed for concentrations of cross-linked N-telopeptides of Type I collagen (NTX). RESULTS: Changes in 4% volumetric BMD, area and strength were greater in EX than CON. At the 38% site, change in bone area and density was greater in EX than CON. The greater change in periosteal circumference in the EX groups also resulted in a greater change in cortical thickness of the tibia compared to the CON group. NTX concentration was lower in the EX group than the CON group after the intervention. CONCLUSIONS: This study documents for the first time the beneficial response of trabecular and cortical bone of black children to a weight bearing exercise intervention.

Full text (sometimes free) may be available at these link(s):      help