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Effects of different physical exercises on leptin concentration in obese adolescents
Ackel-d'Elia C, Carnier J, Bueno CR Jr, Campos RMS, Sanches PL, Clemente APG, Tufik S, de Mello MT, Damaso AR
International Journal of Sports Medicine 2014 Feb;35(2):164-171
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

In order to compare the effects of leisure physical activity (LPA), aerobic training (AT) and aerobic plus resistance training (AT+RT) as part of a 6-month interdisciplinary therapy in body composition, insulin resistance and leptin concentrations in obese adolescents, 72 volunteers (n = 24 in each group) ages 15 to 19 years were evaluated. Delta body mass (kg) and delta BMI (kg/m2) was different between AT and LPA groups and in AT+RT group compared to both LPA and AT groups; delta body fat mass (kg and %) was different only in AT+RT group compared to both LPA and AT; body lean mass (%) was different only in AT+RT group; body lean mass (kg) was negative only in AT and positive and different from AT in AT+RT group; delta HOMA-IR did not differ among groups; delta leptin (ng/ml) was negative and different from LPA for both AT and AT+RT groups. In conclusion, both AT and AT+RT promoted a reduction on leptin levels, however, the adolescents subjected to AT+RT presented better results in body composition than the AT group. These results highlight the importance of associating aerobic and resistance training with nutritional and psychological approaches in the treatment of obese adolescents.

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