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| Influence of aerobic training and detraining on serum BDNF, insulin resistance, and metabolic risk factors in middle-aged men diagnosed with metabolic syndrome |
| Damirchi A, Tehrani BS, Alamdari KA, Babaei P |
| Clinical Journal of Sport Medicine 2014 Nov;24(6):513-518 |
| clinical trial |
| 4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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OBJECTIVE: To study the influence of aerobic exercise training on brain-derived neurotrophic factor (BDNF), insulin resistance, and lipid profile in middle-aged men diagnosed with metabolic syndrome (MetS). DESIGN: This is an experimental repeated measure study. SETTING: Subjects participated in aerobic training programs (18 sessions of 25 to 40 minutes per session) in Guilan University gymnasium and court. PARTICIPANTS: A total of 21 middle-aged men (50 to 65 years old) diagnosed with MetS participated. INTERVENTIONS: We randomly divided 21 middle-aged men with MetS into exercise and control groups. The exercise group followed an aerobic training program (18 sessions, 3/wk) at 50% to 60% of VO2peak (25 to 40 minutes per session) and 6 weeks of detraining. Blood samples were collected at baseline, end of the training, and detraining. MAIN OUTCOME MEASURES: High BDNF level in patients with MetS and its reduction after chronic aerobic exercise. RESULTS: Aerobic training significantly decreased all the metabolic risk factors, including overall MetS z score, insulin resistance, and lipid profile (p < 0.05). After the detraining period, plasma triglyceride, high-density lipoprotein, and also overall MetS z score remained unchanged (p < 0.05); however, serum BDNF, which was decreased by aerobic training (p = 0.013), restored to the baseline at the end of the detraining (p = 0.018). CONCLUSIONS: Improved metabolic risk factors along with decreased serum BDNF in response to aerobic training and the opposite direction during the detraining emphasize the importance of physical activity in the treatment of MetS and prevention of related diseases.
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