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Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study
Santiago MDS, Carvalho DS, Gabbai AA, Pinto MMP, Moutran ARC, Villa TR
Arquivos de Neuro-Psiquiatria 2014 Nov;72(11):851-855
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

To compare the preventive treatment benefits of amitriptyline and aerobic exercise or amitriptyline alone in patients with chronic migraine. METHOD: Sixty patients, both genders, aged between 18 and 50 years, with a diagnosis of chronic migraine, were randomized in groups called amitriptyline and aerobic exercise or amitriptyline alone. The following parameters were evaluated: headache frequency, intensity and duration of headache, days of the analgesic medication use, body mass index (BMI), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) scores. RESULTS: In the evaluated parameters, was observed decrease in headache frequency (p = 0.001), moderate intensity (p = 0.048), in headache duration (p = 0.001), the body mass index (p = 0.001), Beck Depression Inventory (p = 0.001) and Beck Anxiety Inventory scores (p = 0.001), when groups were compared in the end of third month. CONCLUSION: In this study, the amitriptyline was an effective treatment for chronic migraine, but its efficacy was increased when combined with aerobic exercise.

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