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Selective dorsal rhizotomy: meta-analysis of three randomized controlled trials
McLaughlin J, Bjornson K, Temkin N, Steinbok P, Wright V, Reiner A, Roberts T, Drake J, O'Donnell M, Rosenbaum P, Barber T, Ferrel A
Developmental Medicine and Child Neurology 2002 Jan;44(1):17-25
systematic review

This study is a comparative analysis and meta-analysis of three randomized clinical trials. Children with spastic diplegia received either 'selective' dorsal rhizotomy (SDR) plus physiotherapy (SDR+PT) or PT without SDR (PT-only). Common outcome measures were used for spasticity (Ashworth scale) and function (Gross Motor Function Measure (GMFM)). Baseline and 9- to 12-month outcome data were pooled (n = 90). At baseline, 82 children were under 8 years old and 65 had Gross Motor Function Classification System level II or III disability. Pooled Ashworth data analysis confirmed a reduction of spasticity with SDR+PT (mean change score difference -1.2; Wilcoxon p < 0.001). Pooled GMFM data revealed greater functional improvement with SDR+PT (difference in change score +4.0, p = 0.008). Multivariate analysis in the SDR+PT group revealed a direct relationship between percentage of dorsal root tissue transected and functional improvement. SDR+PT is efficacious in reducing spasticity in children with spastic diplegia and has a small positive effect on gross motor function.

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A brief summary and a critical assessment of this review may be available at DARE