AIM: To observe the clinical effects of exercise rehabilitation interventions in inpatients with chronic obstructive pulmonary disease (COPD). METHODS: Forty inpatients with COPD were randomly divided into rehabilitation group and control group of 20 each. The control group was treated mainly with drug, while the rehabilitation group was interfered with systematic exercise, besides routine drug treatment. RESULTS: The dyspnoea (0.95 +/- 0.21, t = 1.56), wheezing sound (0.29 +/- 0.08, t = 2.60) and respiratory rate (20.08 +/- 1.56 times/min, t = -3.02) and functional residual capacity (1.64 +/- 0.29 mL, t = -2.86) in the rehabilitation group were improved more significantly than those in the control group (p < 0.05). The total effective rate was significantly higher in the rehabilitation group (90.0%, Chi2 = 4.64, p < 0.05) than the control group, while the average length of hospitalization (33.26 +/- 4.51 d, t = 3.24, p < 0.01) and incidence rate of complication (5.0%, t = 1.75, p < 0.01) were obviously lower than those in the control group. There were no significant differences in forced expiratory volume in first second (FEV1) (61.23 +/- 5.92%, t = 0.84), FEV1/forced vital capacity (FVC) (56.83 +/- 4.32%, t = 3.61), alveolar oxygen partial pressure (PaO2) (11.21 +/- 1.04 kPa, t = 2.48) and partial pressure of carbon dioxide (PaCO2) (5.24 +/- 0.86 kPa, t = 1.64) between the two groups (p > 0.05). Systematic exercise rehabilitation intervention has a better effect on patients with COPD, their clinical symptom and objective activities are significantly better, and quality of life is improved when discharging, but there are no obvious changes in the indexes of their respiratory physiological function.

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