BACKGROUND AND PURPOSE: Exercise therapy is a common intervention for improving postural stability. The purpose of this meta-analysis was to assess the effect of exercise therapy on postural instability in persons with Parkinson disease (PD) based on the available literature, and to evaluate the efficacy across various types of exercise interventions. DATA SOURCES AND STUDY SELECTION: In January 2015, electronic databases (PubMed, Scopus, PEDro) and study reference lists were searched for randomized controlled trials with moderate or high methodological quality (PEDro score > 5), investigating the effect of exercise on postural instability in persons with PD. DATA EXTRACTION AND SYNTHESIS: Three reviewers extracted data and assessed quality. MAIN OUTCOME AND MEASURE: Postural stability as measured using the Berg Balance Scale, postural sway, Timed Up and Go, or Functional Reach test. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated. RESULTS: Twenty-two trials, with a total of 1072 participants, were eligible for inclusion. The pooled estimates of effects showed significantly improved postural instability (SMD 0.23; 95% CI 0.10 to 0.36; p < 0.001) after exercise therapy, in comparison with no exercise or sham treatment. Exercise interventions specifically addressing components of balance dysfunction demonstrated the largest efficacy, with moderate to high effect sizes (SMD 0.43; 95% CI 0.21 to 0.66; p < 0.001). Little or no beneficial effects were observed for interventions not specifically targeted at postural stability (SMD 0.20; 95% CI -0.04 to 0.44; p = 0.11) or for home-based, multicomponent exercise programs (SMD 0.02; 95% CI -0.20 to 0.25; p = 0.86). DISCUSSION AND CONCLUSIONS: Exercise therapies specifically addressing balance dysfunction are an important treatment option for improving postural stability in persons with PD. Future studies should investigate sustainability of the short-term effects and establish the dose-response relationship of balance training in persons with PD.

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