STUDY DESIGN: Randomized controlled trial. BACKGROUND: Many clinical practice guidelines endorse both manual therapy and exercise as effective treatment options for patients with low back pain. To optimize the effects of the treatments recommended by the guidelines, a new intervention known as Kinesio Taping is being widely used in these patients. OBJECTIVES: To determine the effectiveness of Kinesio Taping in patients with chronic nonspecific low back pain when added to a physical therapy program consisting of exercise and manual therapy. METHODS: One hundred forty-eight patients with chronic nonspecific low back pain were randomly allocated to receive 10 (twice weekly) sessions of physical therapy, consisting of exercise and manual therapy, or the same treatment with the addition of Kinesio Taping applied to the lower back. The primary outcomes were pain intensity and disability (5 weeks after randomization) and the secondary outcomes were pain intensity, disability (3 months and 6 months after randomization), global perceived effect, and satisfaction with care (5 weeks after treatment). Data were collected by a blinded assessor. RESULTS: No between-group differences were observed in the primary outcomes of pain intensity (mean difference -0.01 points; 95% confidence interval (CI) -0.88 to 0.85) or disability (mean difference 1.14 points; 95% CI -0.85 to 3.13) at 5 weeks' follow-up. In addition, no between-group differences were observed for any of the other outcomes evaluated, except for disability 6 months after randomization (mean difference, 2.01 points; 95% CI 0.03 to 4.00) in favor of the control group. CONCLUSION: Patients who received a physical therapy program consisting of exercise and manual therapy did not get additional benefit from the use of Kinesio Taping. LEVEL OF EVIDENCE: Therapy, level 1b. Prospectively registered May 28, 2013 at ClinicalTrials.gov (NCT01866332).

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