BACKGROUND: Multiple sclerosis (MS) is a common disease of central nervous system (CNS) that causes sensorimotor complications through demyelination of CNS neurons. This study was aimed to evaluate the effects of aerobic exercise and yoga on the fatigue and general health of patients with multiple sclerosis. METHODS: In this clinical trial, the samples were randomly assigned to three groups of yoga (n = 30), aerobics exercises (n = 30), and control group (n = 30). The data were analyzed by SPSS software using descriptive statistics (mean and standard deviation), ANOVA and independent and pair t-test. RESULTS: The results indicated no significant difference in fatigue and general health among the three groups prior to the study, but after the study, the results showed a significant difference in general health and fatigue in yoga and aerobic exercise groups. CONCLUSION: Yoga and aerobics exercise decreased the fatigue, promoted the general health, and improved the psychological performance and efficiency of MS patients.

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