Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Long term effects on risk factors for cardiovascular disease after 12-months of aerobic exercise intervention -- a worksite RCT among cleaners
Korshoj M, Lidegaard M, Krustrup P, Jorgensen MB, Sogaard K, Holtermann A
PLoS ONE 2016 Aug;11(8):e0158547
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVES: Occupational groups exposed to high occupational physical activity have an increased risk for cardiovascular disease (CVD). This may be explained by the high relative aerobic workload. Enhanced cardiorespiratory fitness reduces the relative aerobic workload. Thus, the aim was to evaluate the 12-months effects of worksite aerobic exercise on risk factors for CVD among cleaners. METHODS: One hundred and sixteen cleaners aged 18 to 65 years were randomized to a group performing aerobic exercise and a reference group receiving lectures. Outcomes were collected at baseline and after 12-months. A repeated measures 2x2 multi-adjusted mixed-model design was applied to compare the between-group differences using intention-to-treat analysis. RESULTS: Between-group differences (p < 0.05) were found favouring the aerobic exercise group: cardiorespiratory fitness 2.15 (SE 1.03) mlO2/min/kg, aerobic workload -2.15 (SE 1.06) %HRR, resting HR -5.31 (SE 1.61) beats/min, high sensitive c-reactive protein -0.65 (SE 0.24) mug/ml. The blood pressure was unaltered. Stratified analyses on relative aerobic workload at baseline revealed that those with relative aerobic workloads > 30% of HRR seems to impose a notable adverse effect on resting and ambulatory blood pressure. CONCLUSION: This long-term worksite aerobic exercise intervention among cleaners led to several beneficial effects, but also potential adverse effects among those with high relative aerobic workloads. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN86682076.

Full text (sometimes free) may be available at these link(s):      help