There is a dearth of reports on possible additive blood pressure (BP)-reducing effect of aerobic exercise on antihypertensive drug in humans. This study investigated the additive BP-reducing effect of aerobic exercise on BP in individuals with uncontrolled hypertension. In this 12-week double-blind study, 120 new-diagnosed individuals with mild-to-moderate hypertension were randomized to receive coamilozide plus 5/10 mg of amlodipine plus aerobic dance or coamilozide plus 5/10 mg of amlodipine alone. Forty-five and 43 participants in exercise and control groups, respectively, completed the 12-week intervention. Addition of aerobic exercise to antihypertensive drug therapy significantly reduced systolic BP (7.1 mmHg (95% confidence interval 5.0 to 9.3); p < 0.001) and diastolic BP (1.7 mmHg (95% confidence interval: 0.4 to 3.0); p = 0.009) at 12 weeks. BP control rate differed significantly between exercise (53.9%) and control (35.3%) groups, p < 0.001. Postintervention, proportion of participants in exercise group who had their number of antihypertensive drug reduced to one (20.3%) differed from that in control group (11.1%); (Chi2 = 11.0; p = 0.001). Combination of aerobic dance and antihypertensive drugs reduces number of antihypertensive drugs needed to achieve BP control and enhances BP control in individuals with hypertension on two antihypertensive drugs.

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