INTRODUCTION: In diabetic patients, levels of inflammatory factors such as hs-CRP are high and reduction of these factors may lead to the reduction of mortality. Therefore, the aim of this study was to examine whether the eight-week aerobic exercise with nettle supplementation would influence on hs-CRP levels in inactive middle-aged women with type II diabetes. MATERIALS AND METHODS: 42 inactive middle-aged women with diabetes with an average age of 57.1 +/- 06.66 years were randomly divided into four groups: control, placebo, aerobic exercise with placebo, and exercise with nettle supplement (NS). Eight-week increasing aerobic exercise program consisted of 3 sessions per week of running on a treadmill for 30 to 55 minutes with intensity of 45 to 65% heart rate reserve. The first week started with low intensity and reached to maximum intensity in the last week. Dose of NS and placebo was 6 cc divided in 3 times and consumed following meals. Blood samples were obtained one day before the first and 48 h after the last training session. RESULTS: After eight weeks, a significant reduction in the hs-CRP levels only was found in the exercise plus NS (p = 0.029), but not in the control, NS and exercise with placebo groups were found. CONCLUSION: It seems that the consumption of nettle supplement with regular aerobic exercise can reduce inflammation in diabetic patients.

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