INTRODUCTION: Appetite influences energy homeostasis. Nesfatin-1 and neuropeptide Y are orexigenic and anorexigenic peptides that play an important role in obesity and energy balance. The aim of this study was to assess the effects of concurrent endurance (treadmill running) and resistance (weight lifting) exercises on serum levels of nesfatin-1, neuropeptide Y and cortisol in sedentary obese men. MATERIALS AND METHODS: In a quasi-experimental study, 30 men aged between 48 to 60 years with BMI > 30 kg/m2, were randomly allocated to the concurrent training and control groups. The training program consists of 12 weeks of concurrent endurance and resistance training. Blood samples were withdrawn, before and 48 hours after the 12 weeks exercise for measurement of nesfatin-1, neuropeptide Y and cortisol were performed. RESULTS: Findings revealed that after 12 weeks concurrent training, the levels of neuropeptide Y increased and cortisol decreased significantly (p < 0.05), whereas significant changes weren't observed in levels of nesfatin-1. Also, a significant reduction in anthropometric indices was observed in training group. CONCLUSION: According to the findings of this study, it can be concluded that 12 weeks of concurrent training, despite the impact on neuropeptide Y and cortical, hasn't any significant effects on nesfatin-1.

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