INTRODUCTION: HSPs70 are included in the large family of proteins that their severely protected structures show their important role in cell main processes structure and act as molecular requirement of others proteins. Existence of this protein in people with breast cancer indicates survival of cancer. This study was performed with aim to determine the effect of interval training on HSP70 and some inflammatory markers among women with breast cancer. METHODS: This study was performed on 30 women with breast cancer in Khoramabad at 2014. The subjects were randomly divided into two groups including control (n = 15) and interval (n = 15). The experimental group performed the exercises for eight weeks, three sessions per week. The blood samples were taken 48 hours before and after the tests in order to investigate the study's variables (HSP70, VO2peak, Il6, insulin). Data was analyzed by SPSS software (version 19) and dependent and independent t-test. P < 0.05 was considered significant. RESULTS: Eight weeks of interval training caused significant reduction in IL-6 and insulin (p = 0.015). Interval training also increased VO2peak and decreased HSP70 in women with breast cancer. CONCLUSION: Eight weeks of interval training significantly reduce the level of HSP70, IL-6 and insulin and significantly increase VO2peak in women with breast cancer.

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