OBJECTIVE: To evaluate the effectiveness of a multifactorial, tailored program of physical therapy to reduce the occurrence of falls among a heterogeneous group of high-risk elderly Singaporeans recently discharged from the emergency department (ED). DESIGN: Randomized controlled trial. SETTING: Communities. PARTICIPANTS: Adults (n = 354) aged > 65 years who were seen in the ED for a fall or fall-related injuries and discharged home. INTERVENTIONS: The intervention primarily consisted of a tailored program of physical therapy focused on progressive training in strength, balance, and gait for a period of 3 months. Participants in the intervention group also received screening and follow-up for vision, polypharmacy, and environmental hazards. Participants in the control group received usual care prescribed by a physician and educational materials on falls prevention. MAIN OUTCOME MEASURES: The primary outcome measure was experiencing at least 1 fall during the 9-month study period (a 3-mo active intervention phase and a 6-mo maintenance phase). Secondary outcome measures were the occurrence of at least 1 injurious fall during the study period and a change in the Short Physical Performance Battery (SPPB) score. Participants were assessed both after 3 and 9 months. RESULTS: During the 9-month study period, 37.8% of the control group and 30.5% of the intervention group fell at least once, which was not statistically significantly different (odds ratio (OR) 0.72; 95% confidence interval (CI) 0.46 to 1.12; p = 0.146). The intervention group had statistically significantly fewer individuals with injurious falls (OR 0.56; 95% CI 0.32 to 0.98; p = 0.041) and less deterioration in physical performance, reflected by a mean difference of 0.6 in SPPB scores (p = 0.029). Multivariate analyses indicated a strong interaction effect between the intervention and the presence of 2 or more major comorbidities; after accounting for this effect, the intervention program reduced the number of people experiencing at least 1 fall (OR 0.34; 95% CI 0.17 to 0.67; p = 0.002). CONCLUSIONS: We observed that in this heterogeneous population, the proportion of participants experiencing at least 1 fall during the study period was not statistically significantly lower in the intervention group compared with the control group. Secondary analyses strongly suggest that individuals with 2 or more major comorbidities do not benefit from a tailored physical therapy program; however, individuals with less comorbidity may substantially benefit.

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