AIMS: High-intensity interval training (HIIT) improves peak oxygen uptake and left ventricular diastology in patients with heart failure with preserved ejection fraction (HFpEF). However, its effects on myocardial strain in HFpEF remain unknown. We explored the effects of HIIT and moderate-intensity aerobic continuous training (MI-ACT) on left and right ventricular strain parameters in patients with HFpEF. Furthermore, we explored their relationship with peak oxygen uptake (VO2peak). METHODS AND RESULTS: Fifteen patients with HFpEF (age 70 +/- 8.3 years) were randomized to either: (i) HIIT (4x4 min, 85 to 90% peak heart rate, interspersed with 3 min of active recovery; n = 9) or (ii) MI-ACT (30 min at 70% peak heart rate; n = 6). Patients were trained 3 days/week for 4 weeks and underwent VO2peak testing and 2D echocardiography at baseline and after completion of the 12 sessions of supervised exercise training. Left ventricular (LV) and right ventricular (RV) average global peak systolic longitudinal strain (GLS) and peak systolic longitudinal strain rate (GSR) were quantified. Paired t-tests were used to examine within-group differences and unpaired t-tests used for between-group differences (alpha = 0.05). Right ventricular average global peak systolic longitudinal strain improved significantly in the HIIT group after training (pre -18.4 +/- 3.2%, post -21.4 +/- 1.7%; p = 0.02) while RV-GSR, LV-GLS, and LV-GSR did not (p > 0.2). No significant improvements were observed following MI-ACT. No significant between-group differences were observed for any strain measure. deltaLV-GLS and deltaRV-GLS were modestly correlated with delta VO2peak (r = -0.48 and r = -0.45; p = 0.1, respectively). CONCLUSIONS: In patients with HFpEF, 4 weeks of HIIT significantly improved RV-GLS.

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