BACKGROUND: Exercise intervention might be beneficial to the patients with osteoporotic vertebral fractures. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the effect of exercise intervention on pain, quality of life and functional mobility of patients with osteoporotic vertebral fractures. METHODS: PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of exercise intervention on osteoporotic vertebral fractures were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcome was pain scores Meta-analysis was performed using random-effect model. RESULTS: Six RCTs involving 425 patients were included in the meta-analysis. Overall, compared with control intervention, exercise intervention was found to significantly reduce the pain scores (std mean difference -0.95; 95% CI -1.37 to -0.53; p < 0.0001) and improve the quality of life (std mean difference 1.09; 95% CI -1.86 to -0.31; p = 0.006), but demonstrated no influence on timed up and go (std mean difference -0.36; 95% CI -0.96 to 0.24; p = 0.24), physical function (std mean difference -0.32; 95% CI -0.72 to 0.08; p = 0.12). CONCLUSIONS: Compared to control intervention, exercise intervention was found to significantly reduce the pain scores and improve the quality of life, but had no influence on timed up and go and physical function.

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