PURPOSE: To review and assess the effect of whole-body vibration in patients with multiple sclerosis. METHOD: We conducted a systematic review and meta-analysis of randomized controlled trials of whole-body vibration (WBV) in patients with multiple sclerosis (MS). Effect on mobility, balance, muscle strength, spasm, gait, fatigue, general well-being and side effects were evaluated. RESULTS: Ten randomized controlled trials qualified the inclusion criteria. Meta-analysis revealed no significant benefit of WBV in Berg balance scale (standard mean difference (SMD) 0.06; 95% confidence interval (CI) -0.54 to 0.66; p = 0.85; I2= 69%) and Timed Up and Go test (SMD -0.15; 95% CI -0.41 to 0.10; p = 0.24; I2= 0%) when compared with outcomes in the control groups. A significant difference in muscle strength was observed in knee extensor (SMD 0.43, 95% CI 0.05 to 0.81; p = 0.03; I2= 0%). There was no sufficient evidence of benefit of WBV in reducing spasm, relieving fatigue, improving gait or for enhancing well-being. CONCLUSION: Limited evidence supported the benefits of WBV therapy on functions of patients with multiple sclerosis. Larger and more high-quality trials are needed.

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