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Side alternating vibration training in patients with mitochondrial disease: a pilot study
Newell C, Ramage B, Robu I, Shearer J, Khan A
Archives of Physiotherapy 2017 Aug 8;7(10):Epub
clinical trial
3/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Side alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise. We hypothesized that patients with mitochondrial myopathies, who experience muscle weakness, may see an improvement in muscle power with SAVT. METHODS: Patients with mitochondrial disease started either a treatment (SAVT) or control phase (standing without vibration) for 12 weeks, then 12 weeks of washout, and then a 12-week cross-over. The main outcome measure was peak jump power (PJP). We compared this to a natural history cohort from clinic. RESULTS: Seven out of 13 patients completed at least 80% of their SAVT sessions and were analyzed. The delta PJP after the control phase was -2.7 +/- 1.7 W/kg (mean +/- SEM), SAVT was +2.8 +/- 0.6 W/kg (p < 0.05) and from the natural history cohort was -2.4 +/- 0.8 W/kg/year. CONCLUSIONS: SAVT is well tolerated and may improve muscle power in mitochondrial disease patients.

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