Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Aerobic exercise for vasomotor menopausal symptoms: a cost-utility analysis based on the active women trial
Goranitis I, Bellanca L, Daley AJ, Thomas A, Stokes-Lampard H, Roalfe AK, Jowett S
PLoS ONE 2017 Sep;12(9):e0184328
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To compare the cost-utility of two exercise interventions relative to a control group for vasomotor menopausal symptoms. DESIGN: Economic evaluation taking a UK National Health Service and Personal Social Services perspective and a societal perspective. SETTING: Primary care. POPULATION: Peri- and postmenopausal women who have not used hormone therapy in the past 3 months and experience >= 5 episodes of vasomotor symptoms daily. METHODS: An individual and a social support-based exercise intervention were evaluated. The former (exercise-DVD), aimed to prompt exercise with purpose-designed DVD and written materials, whereas the latter (exercise-social support) with community exercise social support groups. Costs and outcomes associated with these interventions were compared to those of a control group, who could only have an exercise consultation. An incremental cost-utility analysis was undertaken using bootstrapping to account for the uncertainty around cost-effectiveness point-estimates. MAIN OUTCOME MEASURE: Cost per quality-adjusted life-year (QALY). RESULTS: Data for 261 women were available for analysis. exercise-DVD was the most expensive and least effective intervention. Exercise-social support was Great British Pounds 52 (CIs 18 to 86) and Great British Pounds 18 (CIs -68 to 105) more expensive per woman than the control group at 6 and 12 months post-randomisation and led to 0.006 (CIs -0.002 to 0.014) and 0.013 (CIs -0.01 to 0.036) more QALYs, resulting in an incremental cost-effectiveness ratio of Great British Pounds 8,940 and Great British Pounds 1,413 per QALY gained respectively. Exercise-social support had 80% to 90% probability of being cost-effective in the UK context. A societal perspective of analysis and a complete-case analysis led to similar findings. CONCLUSIONS: Exercise-Social support resulted in a small gain in health-related quality of life at a marginal additional cost in a context where broader wellbeing and long-term gains associated with exercise and social participation were not captured. Community exercise social support groups are very likely to be cost-effective in the management of vasomotor menopausal symptoms.

Full text (sometimes free) may be available at these link(s):      help