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| Effects of exercise on the immune function of pediatric patients with solid tumors: insights from the PAPEC randomized trial |
| Fiuza-Luces C, Padilla JR, Valentin J, Santana-Sosa E, Santos-Lozano A, Sanchis-Gomar F, Pareja-Galeano H, Morales JS, Fleck SJ, Perez M, Lassaletta A, Soares-Miranda L, Perez-Martinez A, Lucia A |
| American Journal of Physical Medicine & Rehabilitation 2017 Nov;96(11):831-837 |
| clinical trial |
| 4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control (n = 11) and exercise group (n = 9)). Although no significant interaction (group x time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interventions are safe in pediatric cancer patients with solid tumors during chemotherapy treatment despite its aggressive, immunosuppressive nature.
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