INTRODUCTION: Osteoporosis is the most common metabolic bone disease that could causes many dangerous fractures. In this condition bone mass reduces, so fractures can easily occur. The aim of this study was assessing the effect of eight weeks of aerobic training on serum parathormone, estrogen and Alkaline phosphatase concentration in women with premature menopause. METHODS: In this study semi-experimental study, in 2014, 21 women with premature menopause (age 35 to 45 year, body mass index (BMI) > 30 kg/m2, height 161.19 +/- 2.64 and weight 83.97 +/- 1.98) were selected by convenience sampling method and they were randomly divided into two groups experimental (n = 10) and control (n = 11). The subject in experimental group had an aerobic training program for eight week (3 sessions in week, each session 45 to 60 minutes, the intensity of exercise was 65 to 75 percent of maximum heart rate). Blood samples were taken from the subjects' 24 hours before the first session and 48 hours after the last training session at end of eight week in order to measure factors such as (parathyroid hormone (PTH), estrogen and some bone metabolism) by using a radioimmunoassay (RIA) and ELISA method in 12 hours of fasting. Then data for inter and between group comparison, paired and ANCOVA test were used (significance level p < 0.05). RESULTS: The result of this study show that, eight weeks aerobic training lead to a significant increase in mean values of serum calcium (p = 0.001), phosphor (p = 0.001), estrogen (p = 0.001), parathormone (p = 0.001) in aerobic training group; while, the amount of alkaline phosphatase did not change at the end of period (p = 0.92). CONCLUSION: Eight weeks aerobic training with 65 to 75 percent of maximum heart rate intensity was efficient in increasing of serum calcium, phosphor, estrogen, parathormone in women with premature menopause. It is concluded that regular training can help to increase bone density and reduces the risk of fractures in women with premature menopause.

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