Researches have accumulated using non-pharmacologic interventions including acupoint stimulation, massage therapy and expressive writing to manage breast cancer-related symptoms. Results from randomized controlled trials (RCTs) can get contradictory. OBJECTIVE: A systematic review and meta-analysis were conducted to determine the effects on the quality of life, negative emotions and disease-related symptoms among women with breast cancer. METHODS: Two independent researchers performed a structured search using data sources including Medline, CINAHL, Cochrane Central Register of Controlled Trials, Embase, PubMed and PsycINFO from the beginning of time until the first week of January 2015. A total of 23 acupoint stimulation, massage therapy and expressive writing RCTs were included in the review. RESULTS: The study showed that no single intervention could be put under the spotlight exhibiting an overall effective result on all measured outcomes; however, looking into each one in detail shows different results in specific outcomes. Among the three interventions, acupoint stimulation has a treatment effect for general pain (MD -1.46, 95% CI -2.38 to -0.53) and fatigue (MD -2.22, 95% CI -3.68 to -0.77), massage therapy has a treatment effect for anxiety (MD -0.50, 95% CI -0.77 to -0.24), and expressive writing has a treatment effect for quality of life (MD 7.18, 95% CI 0.38 to 13.98). The measurement other outcomes showed either ineffective or equivocal results. CONCLUSION: Non-pharmacologic interventions including acupoint stimulation, massage therapy and expressive writing have an effect on a middle-age woman with breast cancer. However, because of limitations, the seemingly promising results should be interpreted with caution.

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