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Temporary suppression of clonus in humans by brief photostimulation
Walker JB
Brain Research 1985 Aug 5;340(1):109-113
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: Yes; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

In this double-blind study, 21 subjects with spastic paraparesis due to chronic spinal cord injury received irradiation to the skin overlying the radial, median and saphenous nerves with a helium-neon laser (632.5 nm, 1 mW, 20 Hz) or sham treatment. Subjects in the experimental group demonstrated complete clonus suppression after 40 s of irradiation, an effect identical to that observed previously after peripheral electrical nerve stimulation. Subjects who received placebo did not demonstrate this phenomenon. Because such laser irradiation produces no detectable thermal effect, the results indicate that photochemical reactions initiated by laser may trigger neural activity.
With permission from Excerpta Medica Inc.

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