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The effect of an exercise intervention on gestational weight gain: the Behaviors Affecting Baby and You (BABY) study: a randomized controlled trial [with consumer summary]
Nobles C, Marcus BH, Stanek EJ III, Braun B, Whitcomb BW, Manson JE, Markenson G, Chasan-Taber L
American Journal of Health Promotion 2018 Mar;32(3):736-744
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

PURPOSE: To examine the effect of a prenatal exercise intervention on gestational weight gain (GWG) and to update meta-analyses. DESIGN: Randomized controlled trial and meta-analysis. SETTING: Obstetrical practices in a Western Massachusetts hospital. PATIENTS: We analyzed 241 ethnically diverse pregnant participants at high risk for gestational diabetes in the Behaviors Affecting Baby and You (BABY) study. A total of 118 participants were randomized to an exercise intervention group and 123 to a comparison health and wellness intervention group. INTERVENTION: A 12-week individually tailored, motivationally matched program designed to increase the compliance with guidelines for exercise during pregnancy (30 min/day). MEASURES: The GWG and compliance with 2009 Institute of Medicine (IOM) guidelines for GWG abstracted from medical records. ANALYSIS: Unadjusted logistic regression, intent-to-treat. Results were added to the existing meta-analyses using a random effects model. RESULTS: Women randomized to the exercise group had a lower mean GWG than the comparison group (-0.97 kg, p value = 0.39) and were less likely to exceed IOM guidelines (odds ratio 0.69, 95% confidence interval (CI) 0.34 to 1.40), but results were not statistically significant. Meta-analyses yielded a -0.63 kg (95% CI -1.17 to -0.08, p = 0.02) reduction in GWG and a 20% reduction in odds of exceeding IOM guidelines (95% CI 0.73 to 0.89) for the exercise intervention. CONCLUSION: Findings from this randomized trial among ethnically diverse women contribute to the results of meta-analyses supporting exercise as a means of attenuating GWG.

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