STUDY DESIGN: Randomized clinical trial. BACKGROUND: The comparative effectiveness between nonthrust manipulation (NTM) and thrust manipulation (TM) for mechanical neck pain has been investigated, with inconsistent results. OBJECTIVE: To compare the clinical effectiveness of concordant cervical and thoracic NTM and TM for patients with mechanical neck pain. METHODS: The Neck Disability Index (NDI) was the primary outcome. Secondary outcomes included the Patient-Specific Functional Scale (PSFS), numeric pain-rating scale (NPRS), deep cervical flexion endurance (DCF), global rating of change (GROC), number of visits, and duration of care. The covariate was clinical equipoise for intervention. Outcomes were collected at baseline, visit 2, and discharge. Patients were randomly assigned to receive either NTM or TM directed at the cervical and thoracic spines. Techniques and dosages were selected pragmatically and applied to the most symptomatic level. Two-way mixed-model analyses of covariance were used to assess clinical outcomes at 3 time points. Analyses of covariance were used to assess between-group differences for the GROC, number of visits, and duration of care at discharge. RESULTS: One hundred three patients were included in the analyses (NTM, n = 55 and TM, n = 48). The between-group analyses revealed no differences in outcomes on the NDI (p = 0.67), PSFS (p = 0.26), NPRS (p = 0.25), DCF (p = 0.98), GROC (p = 0.77), number of visits (p = 0.21), and duration of care (p = 0.61) for patients with mechanical neck pain who received either NTM or TM. CONCLUSION: NTM and TM produce equivalent outcomes for patients with mechanical neck pain. The trial was registered with ClinicalTrials.gov (NCT02619500). LEVEL OF EVIDENCE: Therapy, level 1b.

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