BACKGROUND: Adjuvant acupuncture for the symptomatic treatment of migraine reduces the frequency of headaches and may be at least similarly effective to treatment with prophylactic drugs. METHODS: This article describes an open-label randomized controlled clinical trial with two groups: the intervention group (n = 42) and the waiting-list control group (n = 44). This study occurred at the Czech-Chinese Center for Traditional Chinese Medicine at the University Hospital Hradec Kralove between October 2015 and April 2017. RESULTS: After 12 weeks of acupuncture, the number of migraine days was reduced by 5.5 and 2.0 days in the acupuncture and the waiting-list control groups, respectively, with a statistically significant inter-group difference of 2.0 migraine days (95% CI -4 to -1). A significantly greater reduction in the number of migraine days per 4 weeks was reached at the end of the 6-month follow-up period in the acupuncture versus control groups (delta -4.0; 95% CI -6 to -2). A statistically significant difference was observed in the number of responders to treatment (response defined as at least a 50% reduction in average monthly migraine day frequency) in the acupuncture versus waiting-list control groups (50% versus 27%; p < 0.05) at the end of the intervention. A significantly greater percentage of responders to treatment was noted in the intervention versus control groups at the 6-month follow-up (81% versus 36%; p < 0.001). CONCLUSION: Acupuncture can reduce symptoms and medication use, both short term and long term, as an adjuvant treatment in migraine prophylaxis in Czech patients.

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