OBJECTIVE: To investigate the effect of integrated approach of yoga therapy (IAYT) intervention in individual with knee osteoarthritis. DESIGN: Randomized controlled clinical trail. PARTICIPANTS: Sixty-six individual prediagnosed with knee osteoarthritis aged between 30 and 75 years were randomized into two groups, ie, yoga (n = 31) and control (n = 35). Yoga group received IAYT intervention for 1 week at yoga center of S-VYASA whereas control group maintained their normal lifestyle. OUTCOME MEASURES: The Falls Efficacy Scale (FES), handgrip strength test (left hand LHGS and right hand RHGS), Timed Up and Go Test (TUG), Sit-to-Stand (STS), and right and left extension and flexion were measured on day 1 and day 7. RESULTS: There were a significant reduction in TUG (p < 0.001), right (p < 0.001), and left flexion (p < 0.001) whereas significant improvements in LHGS (p < 0.01), and right extension (p < 0.05) and left extension (p < 0.001) from baseline in yoga group. CONCLUSION: IAYT practice showed an improvement in TUG, STS, HGS, and goniometer test, which suggest improved muscular strength, flexibility, and functional mobility. CTRI REGISTRATION NUMBER: http://ctri.nic.in/Clinicaltrials, identifier CTRI/2017/10/010141.

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