Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
Kerling A, Hartung D, Stubbs B, Kuck M, Tegtbur U, Grams L, Weber-Spickschen TS, Kahl KG
Neuropsychiatric Disease and Treatment 2018 Aug 6;14:1969-1974
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: Sarcopenia leads to physical function impairment and at least to increasing all-cause mortality. There are notes on reduced muscle mass in patients with major depressive disorder (MDD). Whether an exercise intervention counteracts low muscle mass in patients with MDD has not been studied so far. Therefore, our study aimed at examining effects of regular aerobic exercise training on muscle mass in patients with MDD. PARTICIPANTS AND METHODS: Thirty inpatients with MDD were included in the study, of which 20 received an additional supervised exercise program. Ten patients obtained treatment as usual. Muscle mass was measured using MRI before and 6 weeks after the training period (3 times per week for 45 minutes). RESULTS: We found a significant effect of the exercise intervention on the amount of muscle mass depending on age, body mass index, and the physical activity score (p = 0.042). CONCLUSION: Among other positive effects, regular exercise increases muscle mass in patients with MDD and, therefore, should be recommended as an additional treatment tool.

Full text (sometimes free) may be available at these link(s):      help