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Short and long-term effects of pulmonary rehabilitation in interstitial lung diseases: a randomised controlled trial
Perez-Bogerd S, Wuyts W, Barbier V, Demeyer H, van Muylem A, Janssens W, Troosters T
Respiratory Research 2018 Sep 20;19(182):Epub
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Few data are available on the long-term effect of pulmonary rehabilitation (PR) and on long PR programs in interstitial lung diseases (ILD). We aimed to evaluate the effects of PR on exercise capacity (6-Minute Walking Distance, 6MWD; peak work rate, Wmax), quality of life (St George's Respiratory Questionnaire, SGRQ), quadriceps force (QF) and objectively measured physical activity in ILD after the 6-month PR-program and after 1 year. METHODS: 60 patients (64 +/- 11 years; 62% males; 23% with IPF) were randomly assigned to receive a 6 month-PR program or usual medical care. RESULTS: Exercise capacity, quality of life and muscle force increased significantly after the program as compared to control (mean 95%CI (LL to UL); 6MWD +72 (36 to 108) m; Wmax 19 (8 to 29) %pred; SGRQ 12 (-19 to -6) points; QF 10 (1 to 18) %pred). The gain was sustained after 1 year (6MWD 73 (28 to 118) m; Wmax 23 (10 to 35) %pred; SGRQ 11 (-18 to -4) points; QF 9.5 (1 to 18) %pred). Physical activity did not change. CONCLUSIONS: PR improves exercise tolerance, health status and muscle force in ILD. The benefits are maintained at 1-year follow-up. The intervention did not change physical activity. TRIAL REGISTRATION: ClinicalTrials.gov NCT00882817.

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