BACKGROUND: This study aimed to investigate the effect of continuous and interval cardiac rehabilitation exercise training on tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1beta), and interleukin 6 (IL-6) in patients with coronary artery bypass graft (CABG). METHODS: 30 patients with coronary artery bypass graft surgery up to one month ago were randomly selected and assigned to control, and interval and continuous exercise training groups (n = 10 for each one). Subjects performed their special exercise training program for eight weeks based on their groups, interval exercise training: 15 seconds of high-intensity training and 15 seconds of rest, and continuous exercise training: 20 to 25 minutes of moderate-intensity training. Blood samples were collected to evaluate IL-6, TNF-alpha, and IL-1beta. Repeated measure ANOVA was used to show the difference and Bonferron's post hoc test to determine the location of the difference. All statistical analysis were done at the significant level of p < 0.05. FINDINGS: Serum levels of TNF-alpha and IL-1beta decreased significantly after 8 weeks of rehabilitation exercise training in two experimental group. Moreover, a significant difference was seen between exercise training groups, as interval exercise training induced more decline in TNF-alpha and IL-1beta decline compared to continuation exercise training (p < 0.050). Two type of rehabilitation exercise training did not significantly change the level of IL-6 in patients with coronary artery bypass graft (p > 0.050). CONCLUSION: By performing exercise training, especially interval exercise training, the pre-inflammatory indexes reduce, and it prevents postoperative complications such as revascularization and stroke.

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