INTRODUCTION: Diabetes mellitus is one of the most common metabolic disorders and important public health problems. This disease accounts for 9% of all mortalities in the world and can lead to neuropathy, nephropathy, retinopathy, and cardiac disease in the long term. Regarding this, the present study was designed to assess the effect of combined aerobic and resistance training on the beta-endorphin level and its effect on mu receptor in skeletal muscles for reducing glycosis and insulin resistance in sedentary women with type II diabetes mellitus. METHODS: This randomized clinical trial was performed on 18 sedentary women with type II diabetes mellitus aged 40 to 50 years in 2015. Subjects were randomly divided into intervention and control groups. The exercise program was conducted for 8 weeks, three sessions a week. Each session included a 20-minute aerobic training, in addition to a strength training program. Blood samples were collected to investigate the serum levels of beta-endorphin, glucose, and insulin for 48 h before and after intervention. Data analysis was performed in SPSS software (version 16) using Student's, paired sample and independent t tests for normal data and Wilcoxon and Mann-Whitney U tests for abnormal data to estimate intra-group and inter-group differences respectively. P-value less than 0.05 was considered statistically significant. RESULTS: The results indicated that our combined training significantly increased the maximum oxygen uptake, strength and serum levels of beta-endorphin, and decreased glucose and insulin resistance levels (p <= 0.05). CONCLUSION: This study showed that the combined training reduced the glycemic index and the augmented beta-endorphin level. Consequently, this intervention could have a desirable effect on the reduction of risk factors in women with type II diabetes mellitus.

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