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Effects of exercise therapy for knee osteoarthritis
Wang H, Ma Y, Guo Y, Pan Y
International Journal of Clinical and Experimental Medicine 2018;11(9):10009-10014
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: The aim of this study was to evaluate the effects of exercise therapy for knee osteoarthritis. METHODS: A total of 100 patients with knee osteoarthritis were enrolled in this study, diagnosed in Nanjing University of Chinese Medicine, from January 2015 to June 2017. All patients were randomly divided into an observation group (50 cases) and control group (50 cases). Patients in the observation group were given exercise therapy for 12 weeks, while patients in the control group were given simple quadriceps femoris training for 12 weeks. After treatment, patients in both groups were followed up for 6 months. WOMAC scores, gait parameters, and recurrence rates were compared between the two groups. RESULTS: There were no statistical differences in WOMAC scores between the two groups before intervention (p = 0.109). After intervention, WOMAC scores were reduced in both groups compared to before intervention. WOMAC scores of the observation group were significantly lower than the control group (p = 0.019). There were no statistical differences in gait parameters of the two groups before intervention, including step length (p = 0.288), step frequency (p = 0.396), step width (p = 0.519), step angle (p = 0.331), total support phase (p = 0.699), and swing (p = 0.190). After intervention, step length, step frequency, total support phase, and swing were significantly improved in the observation group compared to before intervention (p = 0.019, p = 0.030, p = 0.026, p = 0.031, respectively). Moreover, step length, step frequency, total support phase, and swing phase were significantly better than those of the control group (p = 0.016, p = 0.021, p = 0.040, p = 0.033, respectively). In the control group, only total support phase was significantly improved compared to before intervention (p = 0.031). In addition, during the 6-month follow up period, recurrence rates of the observation group were significantly lower than the control group (p = 0.001). CONCLUSION: Exercise therapy can effectively improve clinical symptoms and joint function of knee osteoarthritis, while reducing recurrence rates.

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